Posted on by admin in Uncategorized | Comments Off on Thermal control of protein association
Congratulations to Dan and colleagues on developing modular protein domains with sharp, tunable, temperature-dependent heterodimerization. Fusing these domains with other proteins provides control over their association and localization using temperature, which can be delivered globally and locally using methods such as focused ultrasound and magnetic hyperthermia.
Piraner DI, Wi Y, Shapiro MG*. Modular thermal control of protein dimerization.bioRxiv preprint
Posted on by admin in Uncategorized | Comments Off on Acoustic manipulation of engineered cells
Congratulations to Di, Diego, Dina, David and collaborators on their discovery that genetically engineered cells encoding gas vesicles can be trapped, patterned and made to dance (video) with ultrasound standing waves.
Congratulations to Avinoam, Atousa and colleagues on their study showing that gas vesicles can be turned into cavitating free bubbles using low frequency ultrasound, enabling their use as molecularly targeted and genetically encoded “explosives”.
Bar-Zion A, Nourmahnad A, Mittelstein DR, Yoo S, Malounda D, Abedi MH, Lee-Gosselin A, Maresca D, Shapiro MG*. Acoustically detonated biomolecules for genetically encodable inertial cavitation. bioRxiv preprint
Posted on by admin in Uncategorized | Comments Off on Biomolecular contrast agents for OCT
Congratulations to George, Dina and our collaborators at OCT Medical and UCSD on developing the first biomolecular, genetically encodable contrast agents for for optical coherence tomography based on the optical properties of gas vesicles.
Posted on by admin in Uncategorized | Comments Off on Mammalian expression of gas vesicles
Congratulations to Arash, Gabrielle, Danny and Ray on their study demonstrating the mammalian expression of gas vesicles. For the first time, ultrasound can be used to image gene expression in mammalian cells.
Farhadi A, Ho GH, Sawyer DP, Bourdeau RW, Shapiro MG*. Ultrasound imaging of gene expression in mammalian cells.Submitted. bioRxiv preprint
Posted on by admin in Uncategorized | Comments Off on X-waves for selective biomolecular ultrasound
Congratulations to David, Danny, Audrey and collaborators on their new ultrasound imaging scheme, which uses cross-propagating sound waves to obtain maximal specificity for imaging non-linear contrast agents such as gas vesicles.
Maresca D#*, Sawyer DP#, Renaud G, Lee-Gosselin A, Shapiro MG*. Nonlinear X-wave ultrasound imaging of acoustic biomolecules.Physical Review X 8, 041002 (2018). article | synopsis
Congratulations to Pradeep, Sonjong, Hunter, Audrey, Vivek, Max, Jenny and Vasant on their new work showing that strong cellular paramagnetism is sufficient for magnetic manipulation and MRI contrast. Their genetic circuit makes bacteria “ultraparamagnetic” by oxidizing and chelating iron in a ferrogel.
Ramesh P, Hwang SJ, Davis HC, Lee-Gosselin A, Bharadwaj V, English MA, Sheng J, Iyer V, Shapiro MG*. Ultraparamagnetic cells formed through intracellular oxidation and chelation of paramagnetic iron.Angewandte Chemie 57, 12385-12389 (2018). article