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Thermal bioswitches for remote control of microbes in Nature Chemical Biology

ncb-cover-2016Congratulations to Dan, Mohamad, Brittany and Audrey on their article in Nature Chemical Biology describing the development of “bacterial thermostats” that allow microbial therapeutics to be controlled remotely using ultrasound, respond to fever, or know when they have exited their host.

Article: Tunable thermal bioswitches for in vivo control of microbial therapeutics.
Press release: Biologists Give Bacteria Thermostat Controls
Video: Scientists Engineer Therapeutic Bacteria to Listen to Us
Highlight: Nature Methods
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Acoustic Protein Nanostructures on the Cover of ACS Nano

 

Congratulations to Anupama, Arash, Suchita, Audrey, Ray and David on their cover article in the September issue of ACS Nano! Their work describes how gas vesicles can be engineered at the level of their protein composition and sequence to exhibit new acoustic properties and molecular targeting.

Article: Molecular Engineering of Acoustic Protein Nanostructures
Press release: Designing ultrasound tools with lego-like proteins

Third Annual Shapiro Lab Beach Party

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Hermosa Beach, California, July 16, 2016. Thanks to everyone who came!

Second Annual Shapiro Lab Beach Party

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Beautiful day at the ocean! Corona Del Mar, California, August 1, 2015

Reporter gene for Hyperpolarized MRI published in Nature Chemistry

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Our article on “Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging” has been published in Nature Chemistry. It describes how the the xenon-binding capabilities of gas vesicles allow them to be detected non-invasively at picomolar concentrations.

Link to the Article
Editor’s Choice in Science Translational Medicine

 
NATURE

First annual Shapiro Lab beach party

Thanks to all the lab members, family and friends who joined us for our first annual beach party at Bosla Chica beach!

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Ultrasound work published in Nature Nanotechnology

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Our article on the use of microbe-derived gas vesicles as molecular imaging agents for ultrasound has been published.

Link to the Article

News and Views by Mark Borden

Ultrasound movie of injected gas vesicles

Congratulations to everyone involved in this study and our continuing work on genetically encoded and engineered imaging agents for ultrasound!

Lab Renovation Completed!

The Shapiro Lab has officially moved into our newly renovated space in 126 Spalding.
Shapiro Lab AC Martin  /   Photo by Tom Bonner

World Molecular Imaging Congress

The Shapiro Lab attended the World Molecular Imaging Congress in Savannah, GA. Photos: (Left) Dinner with Pradeep, Paula Deen, George and Mikhail. (Right) Mikhail delivering a Young Investigator Award talk at the closing ceremony.
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Announcement: Boswell Fellowship

Caltech is recruiting for the James Boswell Postdoctoral Fellowship in Molecular Engineering and Magnetic Resonance Imaging – a prestigious endowed fellowship to be hosted by the Shapiro Lab and the Huntington Medical Research Institute. Details and application instructions can be found here.