{"id":1234,"date":"2020-07-30T21:26:27","date_gmt":"2020-07-31T04:26:27","guid":{"rendered":"https:\/\/shapirolabnew.che.caltech.edu\/?p=1234"},"modified":"2020-08-22T13:33:37","modified_gmt":"2020-08-22T20:33:37","slug":"thermal-control-of-engineered-t-cells","status":"publish","type":"post","link":"https:\/\/shapirolab.caltech.edu\/?p=1234","title":{"rendered":"Thermal control of engineered T-cells"},"content":{"rendered":"<p>Congratulations to Mohamad, Justin and Dan on their new paper in <em>ACS Synthetic Biology<\/em> describing genetic circuits allowing engineered T-cell immunotherapies to be controlled with temperature. Their work creates the possibility of controlling T-cells inside the body with brief pulses of heat delivered by focused ultrasound, magnetic hyperthermia or infrared light.<br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/shapirolab.caltech.edu\/wp-content\/uploads\/2020\/07\/Graphical-abstract-01-sm.png\" alt=\"\" width=\"487\" height=\"185\" class=\"size-full wp-image-1242\" srcset=\"https:\/\/shapirolab.caltech.edu\/wp-content\/uploads\/2020\/07\/Graphical-abstract-01-sm.png 974w, https:\/\/shapirolab.caltech.edu\/wp-content\/uploads\/2020\/07\/Graphical-abstract-01-sm-300x114.png 300w, https:\/\/shapirolab.caltech.edu\/wp-content\/uploads\/2020\/07\/Graphical-abstract-01-sm-768x293.png 768w\" sizes=\"auto, (max-width: 487px) 100vw, 487px\" \/><br \/>\nAbedi MH, Lee J, Piraner DI, Shapiro MG*. <strong>Thermal control of engineered T-cells.<\/strong> <em>ACS Synthetic Biology<\/em> 9, 1941-50 (2020). <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acssynbio.0c00238\">article<\/a> | <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.16.045146v1\">bioRxiv preprint<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Mohamad, Justin and Dan on their new paper in ACS Synthetic Biology describing genetic circuits allowing engineered T-cell immunotherapies to be controlled with temperature. Their work creates the &hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1234","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1234"}],"version-history":[{"count":12,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1234\/revisions"}],"predecessor-version":[{"id":1254,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1234\/revisions\/1254"}],"wp:attachment":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}