{"id":1442,"date":"2022-03-24T13:37:00","date_gmt":"2022-03-24T20:37:00","guid":{"rendered":"https:\/\/shapirolab.caltech.edu\/?p=1442"},"modified":"2022-04-24T13:38:34","modified_gmt":"2022-04-24T20:38:34","slug":"ultrasound-controlled-probiotic-therapy","status":"publish","type":"post","link":"https:\/\/shapirolab.caltech.edu\/?p=1442","title":{"rendered":"Ultrasound-controlled probiotic therapy"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/shapirolab.caltech.edu\/wp-content\/uploads\/2022\/04\/image.png\" alt=\"\" class=\"wp-image-1443\" width=\"270\" height=\"171\"\/><\/figure><\/div>\n\n\n\n<p>Can we activate the production of immunotherapy drugs specifically inside solid tumors? Yes, by engineering gene circuits in tumor-homing bacteria to take commands from thermal focused ultrasound. Congratulations to Mohamad, Michael and collaborators on this new paper demonstrating the local delivery of checkpoint inhibitors inside solid by ultrasound-controlled probiotic agents. <\/p>\n\n\n\n<p>Abedi MH#, Yao M#, Mittelstein DR, Bar-Zion A, Swift MB, Lee-Gosselin A, Barturen-Larrea P, Buss MT, Shapiro MG*.\u00a0<strong>Ultrasound-controllable engineered bacteria for cancer immunotherapy<\/strong>.\u00a0<em>Nature Communications<\/em>\u00a013, 1585 (2022).\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-29065-2\">article<\/a> | <a href=\"https:\/\/www.caltech.edu\/about\/news\/fighting-cancer-with-sound-controlled-bacteria\">press<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Can we activate the production of immunotherapy drugs specifically inside solid tumors? Yes, by engineering gene circuits in tumor-homing bacteria to take commands from thermal focused ultrasound. Congratulations to Mohamad, &hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1442","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1442","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1442"}],"version-history":[{"count":3,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1442\/revisions"}],"predecessor-version":[{"id":1446,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=\/wp\/v2\/posts\/1442\/revisions\/1446"}],"wp:attachment":[{"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1442"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1442"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shapirolab.caltech.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1442"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}