Molecular Engineering Imaging and Control

We engineer biomolecules with unusual physical properties and use them to image and control biological function non-invasively, e.g. using magnetic fields and sound waves.

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  • Welcome to the Shapiro Lab at the California Institute of Technology.
  • Pasadena, California, USA.
Bioacoustics

Bioacoustics

Ultrasound imaging with genetically encoded gas nanostructures.
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Biomagnetism

Biomagnetism

New molecules and mechanisms for genetically encoded MRI contrast.
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Biophysics

Biophysics

Biophysics of neuromodulation with ultrasound and other forms of energy.
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Biochemistry

Biochemistry

Multiplexed chemical control of the nervous system.
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Thermal bioswitches for remote control of microbes in Nature Chemical Biology

graphical-abstract-v2Congratulations to Dan, Mohamad, Brittany and Audrey on their new article in Nature Chemical Biology describing the development of “bacterial thermostats” that allow microbial therapeutics to be controlled remotely using ultrasound, respond to fever, or know when they have exited their host.

Article: Tunable thermal bioswitches for in vivo control of microbial therapeutics.

Press release: Biologists Give Bacteria Thermostat Controls

Video: Scientists Engineer Therapeutic Bacteria to Listen to Us

Looking inside an MRI voxel

Congratulations to Hunter, Pradeep, Aadyot, Audrey and our collaborators at Harvard on a new study using NV diamond magnetometry to examine the microscale origins of MRI contrast. A preprint describing this work has been posted on arXiv.

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Acoustic Protein Nanostructures on the Cover of ACS Nano

 

Congratulations to Anupama, Arash, Suchita, Audrey, Ray and David on their cover article in the September issue of ACS Nano! Their work describes how gas vesicles can be engineered at the level of their protein composition and sequence to exhibit new acoustic properties and molecular targeting.

Article: Molecular Engineering of Acoustic Protein Nanostructures

Third Annual Shapiro Lab Beach Party

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Hermosa Beach, California, July 16, 2016. Thanks to everyone who came!

New class of reporter genes for diffusion-weighted MRI

Congratulations to Arnab, Di and Hunter for their work on aquaporins as a new class of sensitive, metal-free, non-toxic reporter genes for diffusion-weighted magnetic resonance imaging, just posted on bioRxiv. We are also excited to join the digital revolution in rapid dissemination of scientific results, in the footsteps of George Church, Jim Collins, Pam Silver and other early adopters of bioRxiv. More to come!

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Second Annual Shapiro Lab Beach Party

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Beautiful day at the ocean! Corona Del Mar, California, August 1, 2015

Reporter gene for Hyperpolarized MRI published in Nature Chemistry

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Our article on “Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging” has been published in Nature Chemistry. It describes how the the xenon-binding capabilities of gas vesicles allow them to be detected non-invasively at picomolar concentrations.

Link to the Article
Editor’s Choice in Science Translational Medicine

 
NATURE

First annual Shapiro Lab beach party

Thanks to all the lab members, family and friends who joined us for our first annual beach party at Bosla Chica beach!

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Ultrasound work published in Nature Nanotechnology

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Our article on the use of microbe-derived gas vesicles as molecular imaging agents for ultrasound has been published.

Link to the Article

News and Views by Mark Borden

Ultrasound movie of injected gas vesicles

Congratulations to everyone involved in this study and our continuing work on genetically encoded and engineered imaging agents for ultrasound!

Lab Renovation Completed!

The Shapiro Lab has officially moved into our newly renovated space in 126 Spalding.
Shapiro Lab AC Martin  /   Photo by Tom Bonner