Posted on by admin in Uncategorized | Comments Off on Acoustic biosensors of enzyme activity
Congratulations to Anu, Zhiyang, Suchita and colleagues on their new paper in Nature Chemical Biology describing the first acoustic biosensors. These biosensors turn on nonlinear ultrasound contrast in response to protease activity. This allows the action of enzymes such as TEV, Calpain and ClpXP to be visualized in cells deep inside the body.
Lakshmanan A#, Jin Z#, Nety SP, Sawyer DP, Lee-Gosselin A, Malounda D, Swift MB, Maresca D, Shapiro MG*. Acoustic biosensors for ultrasound imaging of enzyme activity.Nature Chemical Biology (2020). article | readcube
Posted on by admin in Uncategorized | Comments Off on Ultrasound imaging of gene expression in mammalian cells
Congratulations to Arash, Gabrielle, Danny and Ray on their new paper in Science describing the mammalian expression of gas vesicles. For the first time, ultrasound can be used to image gene expression in mammalian cells.
Farhadi A, Ho GH, Sawyer DP, Bourdeau RW, Shapiro MG*. Ultrasound imaging of gene expression in mammalian cells.Science 365, 1469 (2019). article | perspective | news
Posted on by admin in Uncategorized | Comments Off on Thermal control of protein association
Congratulations to Dan and Echo on their publication describing modular protein domains with sharp, tunable, temperature-dependent heterodimerization. Fusing these domains with other proteins provides control over their association and localization using temperature, which can be delivered globally and locally using methods such as focused ultrasound and magnetic hyperthermia.
Piraner DI, Wu Y, Shapiro MG*. Modular thermal control of protein dimerization.ACS Synthetic Biology 8, 2256-2262 (2019). article
Congratulations to David, Audrey, Bill, Dina and collaborators in Paris on demonstrating enhanced non-invasive imaging of neural activity in mice using intravascular gas vesicles as boosters of hemodynamic functional ultrasound contrast.
Maresca D, Payen T, Lee-Gosselin A, Ling B, Malounda D, Demene C, Tanter M, Shapiro MG*. Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity.NeuroImage (2019). article
Posted on by admin in Uncategorized | Comments Off on Acoustic manipulation of engineered cells
Congratulations to Di, Diego, Dina, David and collaborators on their discovery that genetically engineered cells encoding gas vesicles can be trapped, patterned and made to dance (video) with ultrasound standing waves.
Congratulations to Avinoam, Atousa and colleagues on their study showing that gas vesicles can be turned into cavitating free bubbles using low frequency ultrasound, enabling their use as molecularly targeted and genetically encoded “explosives”.
Bar-Zion A, Nourmahnad A, Mittelstein DR, Yoo S, Malounda D, Abedi MH, Lee-Gosselin A, Maresca D, Shapiro MG*. Acoustically detonated biomolecules for genetically encodable inertial cavitation. bioRxiv preprint
Posted on by admin in Uncategorized | Comments Off on Biomolecular contrast agents for OCT
Congratulations to George, Dina and our collaborators at OCT Medical and UCSD on developing the first biomolecular, genetically encodable contrast agents for for optical coherence tomography based on the optical properties of gas vesicles.