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Auditory effects of ultrasonic neuromodulation

Two new bioRxiv manuscripts from Caltech (with Tomo Sato and Doris Tsao) and the University of Minnesota (led by Hongsun Guo and Hubert Lim) describe a major effect of focused ultrasound on neural circuits. Congratulations to both teams on this rigorous scientific contribution to the field of ultrasonic neuromodulation.
Sato T*, Shapiro MG*, Tsao DY*. Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism.
Guo, H, Lim HH et al. Ultrasound produces extensive brain activation via a cochlear pathway.

Shapiro Lab Holiday Party 2017

Celebrating a great year! Photobooth

Artificial ATOMS for microscale device localization

ATOMS-CoverCongratulations to Manuel, Audrey, and our collaborator in Electrical Engineering Azita Emami on the publication of a new approach to localizing microscale integrated circuits in the body using the principles of nuclear magnetic resonance.

Article: Localization of microscale devices in vivo using addressable transmitters operated as magnetic spins (ATOMS)

News and views


Detailed Protocol on Gas Vesicle Production


Interested in making your own gas vesicles for ultrasound or MRI? An (excruciatingly) detailed protocol on GV production, purification, functionalization and imaging has just been published in Nature Protocols. Thanks to Anupama, George, Arash, Suchita, colleagues and collaborators on putting together this valuable resource.

Article: Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI


Fourth Annual Shapiro Lab Beach Party


Dana Point, CA, August 26, 2017. Thanks to all the lab members, collaborators and friends who joined us!

Nonlinear Imaging of Acoustic Biomolecules

Website-01Congratulations to David, Anu, Audrey, Johan, Yu-Li, Ray and our collaborator Dennis Kochmann on their article in Applied Physics Letters describing the development of nonlinear pulse sequences to maximize ultrasound contrast from gas vesicle protein nanostructures.

Article: Nonlinear ultrasound imaging of nanoscale acoustic biomolecules

See also a complementary article in Ultrasound in Medicine and Biology with collaborators at UofT detailing gas vesicles’ acoustic behavior.

New class of MRI reporter genes in Nature Communications

fig1a-illusCongratulations to Arnab, Di and Hunter on their article in Nature Communications describing the membrane water channel aquaporin as a new class of reporter genes for magnetic resonance imaging.

Article: Non-invasive imaging using reporter genes altering cellular water permeability
Press release: Visualizing Gene Expression with MRI

Thermal bioswitches for remote control of microbes in Nature Chemical Biology

ncb-cover-2016Congratulations to Dan, Mohamad, Brittany and Audrey on their article in Nature Chemical Biology describing the development of “bacterial thermostats” that allow microbial therapeutics to be controlled remotely using ultrasound, respond to fever, or know when they have exited their host.

Article: Tunable thermal bioswitches for in vivo control of microbial therapeutics.
Press release: Biologists Give Bacteria Thermostat Controls
Video: Scientists Engineer Therapeutic Bacteria to Listen to Us
Highlight: Nature Methods

Looking inside an MRI voxel

Congratulations to Hunter, Pradeep, Aadyot, Audrey and our collaborators at Harvard on a new study using NV diamond magnetometry to examine the microscale origins of MRI contrast. A preprint describing this work has been posted on arXiv.


Acoustic Protein Nanostructures on the Cover of ACS Nano


Congratulations to Anupama, Arash, Suchita, Audrey, Ray and David on their cover article in the September issue of ACS Nano! Their work describes how gas vesicles can be engineered at the level of their protein composition and sequence to exhibit new acoustic properties and molecular targeting.

Article: Molecular Engineering of Acoustic Protein Nanostructures
Press release: Designing ultrasound tools with lego-like proteins