Thermal control of engineered T-cells

Congratulations to Mohamad, Justin and Dan on their new paper in ACS Synthetic Biology describing genetic circuits allowing engineered T-cell immunotherapies to be controlled with temperature. Their work creates the possibility of controlling T-cells inside the body with brief pulses of heat delivered by focused ultrasound, magnetic hyperthermia or infrared light.

Abedi MH, Lee J, Piraner DI, Shapiro MG*. Thermal control of engineered T-cells. ACS Synthetic Biology 9, 1941-50 (2020). article | bioRxiv preprint